At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What's happening in state-of-the-art in research? No Priors is your guide to the AI revolution. Email feedback to show@no-priors.com.Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or Software 3.0 companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners.Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.
The Rise of the Full-Stack Builder and Hyper-Leveraged Generalist with Microsoft CEO Satya Nadella
June 4, 2026
What does it mean for a business to truly operate at the AI frontier? In a special crossover episode at Microsoft Build, Sarah Guo and Elad Gil team up with Latent Space host “swyx” to talk with Microsoft Chairman and CEO Satya Nadella about the future of AI platforms, software development, and the tech ecosystem. Satya reflects on the latest breakthroughs from Microsoft Build, the strategic shift toward multi-model harnesses, and why private evaluations (evals) are now a company’s most important intellectual property. They also discuss how autonomous AI agents are reshaping the role of software engineers, the durability of SaaS business models, and why showing communities the ROI on data centers is so critical. Plus, Satya shares his thoughts on the economic and societal impacts of the token economy, as well as the future of AI-driven education startups.
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Chapters:
00:00 – Satya Nadella Introduction
01:48 – Reflections from Microsoft Build
03:12 – Microsoft’s AI Training Strategy
05:48 – Complexity of Real-World Deployment of AI
07:33 – Augmenting Human Capital
09:37 – Harnesses for Enterprise
11:49 – Developer Value
15:09 – Can Everybody Operate at the Frontier with Their Frontier Intelligence?
15:51 – Modern Definition of IP
17:38 – Future of Vendor vs. Enterprise Agents
21:48 – Near-Term Predictions on Model Pricing
24:02 – Durability of SaaS
25:58 – What Satya’s Building
28:18 – Future of Engineering Roles
30:54 – How Microsoft Can Be More Ambitious
34:36 – Data Centers and Community Impact
38:01 – AI’s Impact on Society
39:52 - AI and Education
42:28 – Conclusion
Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
May 28, 2026
We are now closer than ever before to living in a world where AI agents are smart enough to run our power grids and manage water supplies. How do we keep them from going rogue? Sarah Guo sits down with Maxim Bar Kogan, founder and CEO of Onyx Securities, to explore the complexities of supervising and securing autonomous agents at the enterprise level. Maxim explains Onyx’s product as an AI control plane, which oversees the permissions and flexible contexts of agents while balancing latency, cost, and reliability. He also discusses how current controls have insufficient context to monitor agent intent, tradeoffs for gradual model rollout, the need for vendor-independent oversight, and Israel’s growing AI and security talent ecosystem. Plus, why Maxim is all-in on AGI.
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Chapters:
00:00 – Cold Open
00:45 – Maxim Bar Kogan Introduction
01:10 – AutoGPT and Betting on Agent Actions
05:17 – What Onyx Product Does
07:47 – State of Deployment in Large Enterprises
09:58 – Securing Agents
12:45 – Why Proxies Don’t Work
14:11 – Why Onyx Trains Its Own Models
18:38 – Onyx’s Talent Culture
21:24 – Mechanistic Interpretability
23:35 – How Onyx Builds Customer Trust
25:10 – Mitigating Risk at the Foundational Level
27:45 – Phased Rollout of Glasswing and Daybreak
29:11 – Large Enterprise Holdouts
30:46 – Onyx and the Larger AI Security Space
32:36 – Should Labs Address Model Trust and Governance?
36:56 – What Needs to Happen in Security
39:14 – Why Maxim is AGI-Pilled
41:15 – Conclusion
The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman
May 21, 2026
Companies in Silicon Valley from Nvidia to AMD are racing to fuel the AI revolution with postage stamp-sized AI chips. Meanwhile, a chip the size of a dinner plate just fueled a $63 billion IPO for Cerebras. Elad Gil and Sarah Guo sit down with Cerebras founder and CEO Andrew Feldman to discuss the company’s journey to making one of the largest tech go-publics in history. Andrew details the multi-year journey of pioneering wafer-scale AI computing, including surviving a brutal period of being ahead of market demand. He also explains the engineering breakthroughs that led to delivering inference speeds at 20x that of standard GPUs. Andrew then shares how a remarkable $20 billion deal with OpenAI came together in only four weeks. Plus, Andrew’s thoughts on why architecting the future of AI requires the fortitude to be a “professional David” against the Goliaths of tech.
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Chapters:
00:00 – Cold Open
00:36 – Andrew Feldman Introduction
01:19 – Cerebras’ Evolution
02:48 – Wafer-Scale Bet Pays Off
06:38 – Challenges and Breakthroughs
08:37 – Crossing the Market Chasm
10:38 – Scaling Software and Hardware
12:03 – Relevance of AI-Generated Coding
13:31 – Leadership and Hiring Culture
17:16 – When to Quit vs. Persist
19:40 – Why Cerebras Went Public
22:57 – The OpenAI Deal
25:54 – Open Source and Post-Trained Workloads
27:37 – How Speed Opens Up New Business
30:33 – Conclusion
Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg
May 14, 2026
Securing AI dominance requires more than just semiconductors; it demands a complete overhaul of how the West manages everything that goes into them, from rare earth minerals to actuators. Enter: Pax Silica. Sarah Guo and Elad Gil sit down with US Under Secretary of State for Economic Affairs Jacob Helberg to discuss the launch and expansion of Pax Silica, a 14-country economic security coalition designed to secure the entire AI supply chain. Jacob talks about the creation of a forward-deployed industrial base in the Philippines, where 4,000 acres will be developed into an “economic security zone.” He also compares and contrasts Pax Silica with China’s Belt and Road initiative, explains how the US plans to reindustrialize through automation and robotics, and explores how the Trump administration envisions making these policies durable across future presidencies. Plus, we hear why Jacob believes America to be a “global underdog.”
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Chapters:
00:00 – Cold Open
00:41 – Jacob Helberg Introduction
01:02 – Pax Silica’s Mission
03:51 – Investing in AI Chip Supply Chains
05:43 – Comparing Pax Silica to China’s Belt and Road Initiative
12:38 – Pax Silica’s Value Proposition
14:38 – US vs. Partnered Manufacturing
19:10 – Rare Earth Mineral Pricing
22:16 – Role of Venture Capital in Pax Silica
24:50 – Near vs. Long-Term Priorities
27:09 – Making AI Policy Durable
28:09 – How Policies Impact Entrepreneurs
31:00 – Trump’s Entrepreneurial Administration
33:00 – Why America is a Global Underdog
38:00 – Conclusion
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
May 11, 2026
The world’s first AI-take-private just proved that AI can revolutionize the real economy. Long Lake Management co-founder and CEO Alexander Taubman joins Elad Gil to discuss his firm’s agreement to acquire the legacy platform American Express Global Business Travel (Amex GBT) in a deal valued at $6.3 billion. Alexander explains the mechanics of AI-driven roll-ups, and why Long Lake chooses to acquire and transform businesses rather than simply selling them software. He also talks about how Long Lake’s horizontal AI platform, Nexus, automates workflows across diverse verticals, and how automation through AI not only powers growth for their portfolio companies, but results in both satisfied customers and employees. Plus, they explore Alexander’s vision of Amex GBT as a multi-decade compounding machine.
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Chapters:
00:00 – Alexander Taubman Introduction
00:30 – Long Lake’s Nexus Platform
03:35 – Retention and Talent Flywheel
05:01 – Acquisition vs. Offering Software
06:57 – Building Long Lake’s Founding Team
10:37 – Taking American Express Global Business Travel Private
13:36 – Taking Berkshire Hathaway’s Approach to Management
16:37 – How AI Strategy Makes Long Lake Stand Out
19:32 – AI Makes Services Scale
22:00 – Conclusion