At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What's happening in state-of-the-art in research? No Priors is your guide to the AI revolution. Email feedback to show@no-priors.com.Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or Software 3.0 companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners.Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.
Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg
May 14, 2026
Securing AI dominance requires more than just semiconductors; it demands a complete overhaul of how the West manages everything that goes into them, from rare earth minerals to actuators. Enter: Pax Silica. Sarah Guo and Elad Gil sit down with US Under Secretary of State for Economic Affairs Jacob Helberg to discuss the launch and expansion of Pax Silica, a 14-country economic security coalition designed to secure the entire AI supply chain. Jacob talks about the creation of a forward-deployed industrial base in the Philippines, where 4,000 acres will be developed into an “economic security zone.” He also compares and contrasts Pax Silica with China’s Belt and Road initiative, explains how the US plans to reindustrialize through automation and robotics, and explores how the Trump administration envisions making these policies durable across future presidencies. Plus, we hear why Jacob believes America to be a “global underdog.”
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Chapters:
00:00 – Cold Open
00:41 – Jacob Helberg Introduction
01:02 – Pax Silica’s Mission
03:51 – Investing in AI Chip Supply Chains
05:43 – Comparing Pax Silica to China’s Belt and Road Initiative
12:38 – Pax Silica’s Value Proposition
14:38 – US vs. Partnered Manufacturing
19:10 – Rare Earth Mineral Pricing
22:16 – Role of Venture Capital in Pax Silica
24:50 – Near vs. Long-Term Priorities
27:09 – Making AI Policy Durable
28:09 – How Policies Impact Entrepreneurs
31:00 – Trump’s Entrepreneurial Administration
33:00 – Why America is a Global Underdog
38:00 – Conclusion
Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
May 11, 2026
The world’s first AI-take-private just proved that AI can revolutionize the real economy. Long Lake Management co-founder and CEO Alexander Taubman joins Elad Gil to discuss his firm’s agreement to acquire the legacy platform American Express Global Business Travel (Amex GBT) in a deal valued at $6.3 billion. Alexander explains the mechanics of AI-driven roll-ups, and why Long Lake chooses to acquire and transform businesses rather than simply selling them software. He also talks about how Long Lake’s horizontal AI platform, Nexus, automates workflows across diverse verticals, and how automation through AI not only powers growth for their portfolio companies, but results in both satisfied customers and employees. Plus, they explore Alexander’s vision of Amex GBT as a multi-decade compounding machine.
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Chapters:
00:00 – Alexander Taubman Introduction
00:30 – Long Lake’s Nexus Platform
03:35 – Retention and Talent Flywheel
05:01 – Acquisition vs. Offering Software
06:57 – Building Long Lake’s Founding Team
10:37 – Taking American Express Global Business Travel Private
13:36 – Taking Berkshire Hathaway’s Approach to Management
16:37 – How AI Strategy Makes Long Lake Stand Out
19:32 – AI Makes Services Scale
22:00 – Conclusion
Baseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference Cloud
May 1, 2026
Baseten CEO and co-founder Tuhin Srivastava sits down with Sarah Guo and Elad Gil to discuss the rapid growth of AI inference demand, Baseten’s 30x growth, and why inference is becoming the strategic “last market.” Tuhin Srivastava argues the application layer will persist because companies with unique user signals can encode value into workflows and post-train specialized models, citing examples like Abridge and support workflows. The conversation covers GPU capacity constraints, Baseten’s multi-cloud fabric across 18 clouds and 90 clusters, long-term contracting dynamics, the importance of the software layer for stickiness, evolving workloads, multichip possibilities, and operational lessons at scale.
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Chapters:
00:31 Baseten growth
01:55 Why the app layer wins
05:57 Serving frontier customers
07:55 Open source model mix
09:21 Chinese models and geopolitics
13:07 Custom inference dominates
14:22 Post training acquisition
17:10 When to invest in custom models
18:35 Supply crunch and data centerse
22:25 Longer GPU Contracts
24:09 What Makes a Winner
26:07 Multi Chip Future
28:19 Runtime Roadmap
31:08 Scaling Edge Cases
33:48 Hiring and Leadership
36:44 Operations Pager Culture
38:19 Efficiency Drives Demand
40:41 Concierge Everything Future
42:34 Conclusion
SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig
April 23, 2026
More than fifty years ago, the modern idea of the standard enterprise software was birthed at SAP. Now, after managing companies through technological shifts from the mainframe to mobile, SAP is at the forefront of closing the AI adoption gap for their customers. SAP Chief Technology Officer Philipp Herzig joins Sarah Guo to talk about how SAP has remained a durable end-to-end “operating system” for its more than 400,000 customers from finance to supply chain. Philipp argues that the AI transition in businesses should focus on customer outcomes, UI changes, business processes, and the data layer. He also explains the challenges in enterprise AI adoption, including security, scaling, and data fragmentation, as well as the importance of evals and verifiability. They also discuss SAP’s suite of AI products, limitations of predictive tabular models, how SAP is shifting its pricing models in the AI era, and Philipp’s interest in quantum computing optimization.
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Chapters:
00:00 – Cold Open
00:42 – Philipp Herzig Introduction
01:18 – What SAP Does
02:51 – Why SAP Endures
06:53 – CTO Priorities and AI Push
12:14 – Scaling AI in Enterprise
17:06 – Verifiability and Agent Mining
20:42 – Tool Calling vs. Computer Use
22:11 – Domains Where Agents Deliver Value
24:58 – Limitations of Predictive Tabular Models
29:07 – Barriers to Enterprise Adoption
31:54 – How AI Will ‘Uplevels’ Work
34:03 – How AI Changes SAP’s Pricing Model
36:41 – What Makes a Winner in the AI Era
38:53 – Day in the Life of a CTO
40:08 – Customer Challenges
42:36 – Business Problem of Quantum Computing
46:21 – Conclusion
Scaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermott
April 17, 2026
Few teens are business owners, but by age 16, Bill McDermott had purchased and was running a local deli. Now he runs leading global technology powerhouse ServiceNow, a company that is defining how the world’s largest organizations transform for the digital age. Sarah Guo sits down with ServiceNow CEO Bill McDermott to discuss his journey from child entrepreneur to CEO, and how he navigates his role as a leader in the age of AI. Bill argues that human connection is still a vital part of being a successful leader, and as such, AI must be used to serve people rather than substitute for ambition. He breaks down the mechanics of hyper-growth, and the art of staying customer-centric at a global scale. They also discuss the future of enterprise software, how generative AI is fundamentally reshaping the labor market, and what founders need to know about building a resilient company culture that survives economic and technological shifts.
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Chapters:
00:00 – Cold Open
00:50 – Bill McDermott Introduction
01:14 – Lesson from Buying a Deli
07:35 – Leadership in the AI Era
09:41 – How Bill Got Hired at Xerox
15:47 – Can Agency Be Taught?
18:40 – Seeing Change as Opportunity
25:18 – ServiceNow as an AI Control Tower
30:30 – Which SaaS Gets Disrupted?
32:22 – Defining a Platform Business
36:25 – Does AI Decrease Implementation Time?
39:06 – Agents Will Reshape the Workforce
40:59 – Success Signals at ServiceNow
44:07 – Enterprise Attitudes About AI
48:41 – How AI Has Changed Customer Conversations
50:48 – Bill’s Curiosity Beyond ServiceNow
52:29 – Day in the Life of a CEO
57:27 – Conclusion